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Зентел (Zentel)
  • Зентел (Zentel)

Зентел (Zentel)

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Price:
500 KZT
Brand:Glaxo Wellcome
Country of manufacture:India
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Description

Pharmacological action:
Zentel is an antiprotozoal and anthelmintic preparation that is part of the benzimidazole group of the carbamate. It acts on intestinal and tissue forms of parasites, active in eggs, larvae and adult helminths. The drug inhibits the polymerization of tubulin, disrupting the metabolism of helminths and leading to their death.
Zentel such active intestinal parasites:
nematode - Trichuris trichiura, Cutaneous Larva Migrans, Ancylostoma duodenale, Ascaris lumbricoides, and Enterobius vermicularis, Strongyloides stercoralis, Necator americanus;
cestodes - Taenia solium, Hymenolepsis nän, Taenia saginata - pork, dwarf and bovine tapeworm;
trematodes - Clonorchis sinensis, Opisthorchis viverrini;
protozoa - Giardia lamblia.
The drug against tissue parasites, including cystic echinococcosis, alveolar echinococcosis, which causes respectively Echinococcus granulosus, Echinococcus multilocularis, is active.
Zentel is effective in neurocysticercosis caused by invasion of Taenia solium larvae, capillariasis caused by Capillaria philippinensis, gnathostomosis caused by Gnathostoma spinigerum. The drug destroys or reduces the size of cysts of granular echinococcus. The number of non - viable cysts after treatment is significantly increased. After the application of Zentel, complete disappearance of cysts caused by Echinococcus multilocularis or stabilization of the disease was noted.
The preparation is slightly absorbed when administered orally. Absorption significantly increases the intake of fatty foods. Zentel is metabolized in the liver. The main metabolite is albendazole sulfate, which is the main effective substance in the treatment of tissue infections. Its T1/2 is about 8.5 hours. Elimination of the drug from cysts after prolonged maintenance in high doses lasts several weeks. Alfendazole sulfate is excreted, as well as its metabolites with bile, a small part - with urine.
Indications:
Zentel Used in intestinal helminth infections forms: enterobioze, hookworm, necatoriasis, gimenolepidoze, taeniasis, strongyloidiasis, ascariasis, trihotsefaleze, clonorchiasis, opistarhoze, giardiasis in children, and in cutaneous syndrome Larva Migrans - short - term treatment at low doses.
The drug is used in systemic helminthic invasions - long - term treatment with high doses.
For cystic echinococcosis caused by Echinococcus granulosus:
- if surgical intervention is not possible;
- before surgical intervention;
- in the postoperative period, if the preoperative treatment was short if the prevalence of helminths is noted, if live forms are revealed during the operation;
- after carrying out for the purpose of diagnosis or therapy of percutaneous drainage.
In case of alveolar echinococcosis caused by Echinococcus multilocularis:
- after surgical palliative treatment;
- with liver transplantation or radical surgical treatment.
In case of neurocysticercosis caused by larvae of Taenia solium:
- with granulomatous lesion of the brain;
- for arachnoidal cysts or intraventricular;
- upon detection of single cysts or multiple;
- with racemose cysts.
Also Zentel is used for capillaria, which is caused by Capillaria philippinensis, gnathostomosis, which is caused by Gnathostoma spinigerum and other related species, trichinosis, which is caused by T. Pseudospiralis and Trichinella spiralis, toxocarose that is caused by Toxocaga canis and other related species.

How to use:
Zentel is accepted along with the food. If clinical improvement does not occur after 3 weeks, a second course of treatment is prescribed. Some patients, more often children experience difficulties in swallowing the pill entirely. In this case, it can be crushed or chewed, mixed with a small amount of water. Shake the resulting suspension before use.
With ankylostomiasis, enterobiosis, noncaratosis of ascaridosis and trichocephalosis, 400 mg of the drug are taken once a day - 1 tablet. When strongyloidosis, as well as shadeosis, hymenolepiasis, 400 mg of the drug per day for 3 days are taken. With hymenolepiasis, a second course is conducted between the 10th and 21st days after the completion of the previous course. When opistarchosis and clonorchosis is taken 400 mg 3 days a day twice. With the Larva Migrans skin syndrome, 400 mg is taken per day, treatment lasts up to 3 days. With pediatric gambliasis treatment is 5 days, 400 mg of the drug is taken per day.
For children of 2 - 3 years, it is recommended to use Zentel in a suspension orally. Children under 2 years of age should not prescribe the drug. With enterobiosis, ankylostomosis, as well as non - katorosis, ascariasis, trichocephalosis, 10 ml of the suspension are administered once. Children up to 2 years of single - time 5 ml of suspension. With strongyloidiasis, teniosis, and hymenolepiasis 3 days for 10 ml of suspension. With hymenolepiasis, the course is repeated between the 10th and 21st days after the completion of the previous course. With clonorchosis and opistarchosis, 10 ml of suspension are administered twice daily for two days. With the Larva Migrans skin syndrome, 10 ml of suspension are taken per day, treatment lasts up to 3 days. With giardiasis treatment lasts 5 days, 10 ml of suspension is taken per day.
In the treatment of patients with hepatic impairment, prescribe the drug with caution, but adjust the dose is not required.
In case of renal insufficiency, correction of the dose of the drug is not needed, since Albendazole is secreted in small amounts by the kidneys.
For systemic helminth invasions with long - term treatment with high doses, the drug should be taken with food. High doses of Zentela for children under 6 years are not recommended. The dose is set individually, depending on the body weight, the severity of infection and age. For patients weighing up to 60 kg, 400 mg of the drug or 10 ml of suspension per day are prescribed 2 times. Patients over 60 kg are prescribed a drug in the calculation of 15 mg/kg/day. The dose is divided into 2 doses.
In cystic echinococcosis, the treatment is 28 days. The cycle can be reassigned after the previous course in 2 weeks. With inoperable and multiple cysts, up to 3 cycles of 28 days are prescribed for the treatment of pulmonary, peritoneal, hepatic cysts. If the cysts have a different location - in the brain, bones - a longer treatment is prescribed. Before the operation, 2 cycles of 28 days are recommended. If the operation is required before the cycles are completed, then the treatment continues until the operation begins. After the operation and percutaneous drainage of cysts, if a short course of treatment or urgent surgery was performed before the operation, 2 cycles of 28 days, separated by a break for 2 weeks, are performed. When identifying viable cysts or spreading helminths are treated with 2 complete cycles.
In alveolar echinococcosis, the treatment is 28 days. After 2 weeks a repeated course of 28 days is conducted. Treatment can be extended if necessary for several months, years. With neurocysticercosis, the duration of taking Zentela is 7 - 30 days, the duration of admission depends on the response to treatment. After 2 weeks, you can repeat the course. With cysts in the parenchyma, granulomas, the duration of treatment is about 7 - 28 days.
With racemose cysts, treatment lasts a minimum of 28 days. The duration of treatment is determined radiological and clinical response to ongoing treatment. With capillarosis, 400 mg of 10 days are prescribed per day. As a rule, 1 course of treatment is sufficient, but with a positive result of a parasitological examination, an additional course may be required. When Gnatostomose is prescribed for 10 - 20 days 400 mg per day. With trichinosis, toxocarosis take 400 mg per day for 5 - 10 days.
In the treatment of neurocysticercosis, anticonvulsant and GCS therapy is recommended. SCS is prescribed to prevent cerebral hypertension in the first week of treatment.
Before treatment with Zentel, patients with hepatic impairment should be carefully screened. Albendazole in the liver is metabolized to the active metabolite, so a violation of liver function can significantly affect the pharmacokinetics of albendazole. If, during treatment, the level of transmnase increases significantly, or the blood count decreases, treatment should be discontinued.
Side effects:
Immune system: hypersensitivity reactions - itching, rash, urticaria.
CNS: dizziness and headache.
Gastrointestinal tract: nausea, vomiting, as well as abdominal pain, diarrhea.
Hepatobiliary system: the level of hepatic enzymes increases, infrequently hepatitis.
Skin and subcutaneous tissue: Stevens - Johnson syndrome, polymorphic erythema, reversible alopecia.
Blood system, lymphatic system: leukopenia, rarely agranulocytosis, aplastic anemia, pancytopenia.
Common disorders: fever.
Contraindications:
Contraindications to Zentel's use are hypersensitivity to albendazole. The drug for children under 1 year of age is not recommended in any form, children under 3 years of age are contraindicated in pills.
Pregnancy:
Zentel is contraindicated for use during pregnancy, lactation and for treatment of women who plan pregnancy.
Interaction with other drugs:
In conjunction with Zentelom dexamethasone, praziquantel and cimetidine increase in plasma levels of metabolites of albendazole, increasing the risk of overdose. The systemic effect of the drug increases its intake with fatty foods, increasing absorption.
Overdose:
Symptoms of overdose depending on the dose may be nausea, diarrhea, vomiting, as well as tachycardia and increased transaminase levels. Release Form:
Tablets of 400 mg,
Storage conditions:
Store the suspension and tablets at a temperature of no more than 25 degrees Celsius and protect from direct sunlight.
Synonyms:
Albendazole.
Composition:
Albendazole in an amount of 400 mg.
Auxiliary ingredients: sodium carboxymethyl starch, magnesium aluminum silicate, polysorbate 80, glycerol, benzoic acid, potassium sorbate, sorbitan monolaurate, Silicone Antifoam 1510, sorbic acid, sodium saccharin, flavoring, flavoring .
Characteristics:
Brand:Glaxo Wellcome
Country of manufacture:India
Information is up-to-date: 18.03.2024

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